Endocrine Abstracts

Objective: The aim of this study was to investigate sex-specific associations of two established serum selenium biomarkers, i.e. total selenium and selenoprotein P with type 2 diabetes mellitus (T2D) and hypertension in a large cohort of older people.Methods: 1500 participants with available selenium measurements from the Berlin Aging Study II (BASE-II) were included in this study. In the serum samples, spectroscopy was used to quantify total selenium, a...

We have recently demonstrated the high potential of non-viral polyplexes for tumor-specific delivery of the sodium iodide symporter (NIS) after systemic application. In the current study we used novel polymers based on linear polyethylenimine (LPEI), shielded by polyethylene glycol (PEG), and coupled with the synthetic peptide B6 (LPEI-PEG-B6) as a transferrin (Tf)-receptor specific ligand to achieve active tumor targeting to human hepatocellular cancer (HuH7) cells after syst...